Three years ago in Mexico, determined Federale Machete is betrayed and set-up by his boss, resulting in his wife and child being murdered by drug kingpin Torrez. Now, in Texas, Machete resurfaces when hired to assassinate Senator McLaughlin, an extreme advocate against illegal immigration. Once again betrayed and set-up, Machete plots his revenge against the men who've wronged him with the help of resistance fighter Luz, ICE Agent Sartana, and the shotgun-toting Padre.