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| Danny Trejo | ... | Machete (segment "Machete") |
| Cheech Marin | ... | Padre Benicio Del Toro (segment "Machete") |
| Rose McGowan | ... | Cherry Darling (segment "Planet Terror") / Pam (segment "Death Proof") |
| Freddy Rodríguez | ... | El Wray (segment "Planet Terror") |
| Josh Brolin | ... | Dr. William Block (segment "Planet Terror") |
| Marley Shelton | ... | Dr. Dakota Block (segments "Planet Terror" / "Death Proof") |
| Jeff Fahey | ... | J.T. (segment "Planet Terror") / The Well-Dressed Man (segment "Thanksgiving") / The Boss (segment "Machete") |
| Michael Biehn | ... | Sheriff Hague (segment "Planet Terror") / The Sheriff (segment "Thanksgiving") |
| Rebel Rodriguez | ... | Tony Block (segment "Planet Terror") |
| Naveen Andrews | ... | Abby (segment "Planet Terror") |
| Bruce Willis | ... | Lt. Muldoon (segment "Planet Terror") |
| Julio Oscar Mechoso | ... | Romey (segment "Planet Terror") |
| Stacy Ferguson | ... | Tammy (segment "Planet Terror") |
| Nicky Katt | ... | Joe (segment "Planet Terror") / Store clerk (segment "Death Proof") |
| Hung Nguyen | ... | Dr. Crane (segment "Planet Terror") |
| Cecilia Conti | ... | Paramedic #1 (segment "Planet Terror") |
| Tommy Nix | ... | Paramedic #2 (segment "Planet Terror") |
| Tom Savini | ... | Deputy Tolo (segment "Planet Terror") |
| Carlos Gallardo | ... | Deputy Carlos (segment "Planet Terror") |
| Skip Reissig | ... | Skip (segment "Planet Terror") |
| Electra Avellan | ... | Babysitter Twin #1 (segments "Death Proof" / "Planet Terror") |
| Elise Avellan | ... | Babysitter Twin #2 (segments "Death Proof" / "Planet Terror") |
| Michael Parks | ... | Earl McGraw (segments "Planet Terror" / "Death Proof") |
| Quentin Tarantino | ... | The Rapist (segment "Planet Terror") / Warren (segment "Death Proof") |
| Greg Kelly | ... | Rapist #2 (segment "Planet Terror") |
| Jerili Romeo | ... | Ramona McGraw (segment "Planet Terror") |
| Troy Robinson | ... | Soldier #1 (segment "Planet Terror") |
| Derek Southers | ... | Soldier #2 (segment "Planet Terror") |
| Jason Douglas | ... | Lewis (segment "Planet Terror") |
| Felix Sabates | ... | Dr. Felix (segment "Planet Terror") |
| Doran Ingram | ... | Patient (segment "Planet Terror") |
| Johnny Reno | ... | Sax Survivor (segment "Planet Terror") |
| Kurt Russell | ... | Stuntman Mike (segment "Death Proof") |
| Rosario Dawson | ... | Abernathy (segment "Death Proof") |
| Vanessa Ferlito | ... | Arlene / 'Butterfly' (segment "Death Proof") |
| Jordan Ladd | ... | Shanna (segment "Death Proof") / Judy (segment "Thanksgiving") |
| Sydney Tamiia Poitier | ... | Jungle Julia (segment "Death Proof") |
| Tracie Thoms | ... | Kim (segment "Death Proof") |
| Mary Elizabeth Winstead | ... | Lee (segment "Death Proof") |
| Zoe Bell | ... | Zoe (segment "Death Proof") |
| Marcy Harriell | ... | Marcy (segment "Death Proof") |
| Eli Roth | ... | Dov (segment "Death Proof") / Tucker (segment "Thanksgiving") |
| Omar Doom | ... | Nate (segment "Death Proof") |
| Michael Bacall | ... | Omar (segment "Death Proof") |
| Monica Staggs | ... | Lanna Frank (segment "Death Proof") |
| Jonathan Loughran | ... | Jasper (segment "Death Proof") |
| Marta Mendoza | ... | Punky Bruiser (segment "Death Proof") |
| Tim Murphy | ... | Tim the Bartender (segment "Death Proof") |
| Melissa Arcaro | ... | Venus Envy (segment "Death Proof") |
| James Parks | ... | Edgar McGraw (segment "Death Proof") |
| Eurlyne Epper | ... | Lanna Franks Friend #1 (segment "Death Proof") |
| Jamie L. Dunno | ... | Lanna Franks Friend #2 (segment "Death Proof") |
| Helen Kim | ... | Peg (segment "Death Proof") |
| Tina Rodriguez | ... | Juana (segment "Death Proof") |
| Kelley Robins | ... | Laquanda (segment "Death Proof") |
| Jeff Rendell | ... | The Pilgrim (segment "Thanksgiving") |
| Liliya Malkina | ... | The Grandmother (segment "Thanksgiving") |
| Kevin Wasner | ... | The Turkey Pilgrim (segment "Thanksgiving") |
| Jay Hernandez | ... | Bobby (segment "Thanksgiving") |
| Mike McCarty | ... | The Rioter (segment "Thanksgiving") |
| Mark Bakunas | ... | The Deputy (segment "Thanksgiving") |
| Vendula Bednarova | ... | The Cheerleader (segment "Thanksgiving") (as Vendula Kristek) |
| Petr Vancura | ... | The Boyfriend (segment "Thanksgiving") |
| Karel Vanásek | ... | The Grandfather (segment "Thanksgiving") |
| Katherin-Ellen Zabehlicky | ... | The Granddaughter (segment "Thanksgiving") |
| Chris Briggs | ... | The Vomiting Cousin (segment "Thanksgiving") |
| Daniel S. Frisch | ... | The Human Turkey (segment "Thanksgiving") |
| Nicolas Cage | ... | Fu Manchu (segment "Werewolf Women of the SS") |
| Udo Kier | ... | Franz Hess (segment "Werewolf Women of the SS") |
| Sheri Moon Zombie | ... | Eva Krupp (segment "Werewolf Women of the SS") |
| Tom Towles | ... | Lt. Boorman (segment "Werewolf Women of the SS") |
| Sybil Danning | ... | Gretchen Krupp (segment "Werewolf Women of the SS") |
| Andrew Martin | ... | Nazi Boxer (segment "Werewolf Women of the SS") (as Test) |
| Bill Moseley | ... | Dr. Heinrich von Strasser (segment "Werewolf Women of the SS") |
| Oleg Aleksandrovich Prudius | ... | Nazi Boxer (segment "Werewolf Women of the SS") (as Vladimir Kozlov) |
| Olja Hrustic | ... | Werewolf Woman (segment "Werewolf Women of the SS") |
| Meriah Nelson | ... | Werewolf Woman (segment "Werewolf Women of the SS") |
| Lorielle New | ... | Werewolf Woman (segment "Werewolf Women of the SS") |
| Michael Deak | ... | Gun-wielding Werewolf (segment "Werewolf Women of the SS") |
| Jason Isaacs | ... | Bearded Man (segment "Don't") |
| Matthew Macfadyen | ... | Hatchet Victim (segment "Don't") |
| Katie Melua | ... | Brunette with Hatchet Victim (segment "Don't") |
| Stuart Wilson | ... | Old Man (segment "Don't") |
| Simon Pegg | ... | Bearded Cannibal (segment "Don't") |
| Nick Frost | ... | Baby Eater (segment "Don't") |
| Kevin Wilson | ... | Twin #1 (segment "Don't") |
| Nicholas Wilson | ... | Twin #2 (segment "Don't") (as Nick Wilson) |
| Will Arnett | ... | Announcer (segement 'Don't') (voice) |
| Georgina Chapman | ... | Featured Woman (segment "Don't") |
| Emily Booth | ... | Featured Woman (segment "Don't") |
| MyAnna Buring | ... | Featured Woman (segment "Don't") |
| Rafe Spall | ... | Featured Ghost (segment "Don't") |
|
| Elena Kolpachikova | ... | Werewolf Woman (segment "Werewolf Women of the SS") |
| Leroy anon | ... | Sicko (segment "Planet Terror") (uncredited) |
| Jake Garber | ... | Gas Pump Zombie (segment "Planet Terror") (uncredited) |
| Sammy Harte | ... | Infected Girl (segment "Planet Terror") (uncredited) |
| Melanie Jayne | ... | Harem Girl (segment "Werewolf Women of the SS") (uncredited) |
| Stephanie Katz | ... | Werewolf Woman (segment "Werewolf Women of the SS") (uncredited) |
| Tito Larriva | ... | Henchman (segment "Machete") (uncredited) |
| Andrea Lee | ... | Sicko (segment "Planet Terror") (uncredited) |
| Alicia Rachel Marek | ... | Redhead Babe (segment "Machete") (uncredited) |
| John McLean | ... | Sicko Coach (segment "Planet Terror") (uncredited) |
| Rajiv Patel | ... | Henchman (uncredited) |
| Lucy Punch | ... | Running Blond Woman (segment "Don't") (uncredited) |
| Bobbie Ragsdale | ... | Nurse (uncredited) |
| Emmy Robbin | ... | Hot Female Deputy (segment "Planet Terror") (uncredited) |
| Patricia A. Robinson | ... | Infected Patient (uncredited) |
| Robert Rodriguez | ... | Extra (segment "Planet Terror") (uncredited) |
| Christine Rose | ... | Sicko (segment "Planet Terror") (uncredited) |
| Kelly Ryan | ... | Werewolf Woman (segment "Werewolf Women of the SS") (uncredited) |
| Ava Santana | ... | Sicko (segment "Planet Terror") (uncredited) |
| Mikhail Sebastian | ... | Hospital Doctor (segment "Death Proof") (uncredited) |
| Charlita Williams | ... | Survivor (uncredited) |
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