When a college professor opens up a strange, ornate box discovered in the basement of a University, she and her students hear a horrifying scream belonging to a bloodthirsty banshee. They're relieved when it stops, but that scream insidiously begins to haunt all that heard it in strange and surreal ways. At first dismissing the Irish folklore that if you hear a banshee scream, you will die, they soon discover the folklore is truer than they could have imagined, as they begin losing their lives.