|
| Tobey Maguire | ... | Spider-Man / Peter Parker |
| Willem Dafoe | ... | Green Goblin / Norman Osborn |
| Kirsten Dunst | ... | Mary Jane Watson |
| James Franco | ... | Harry Osborn |
| Cliff Robertson | ... | Ben Parker |
| Rosemary Harris | ... | May Parker |
| J.K. Simmons | ... | J. Jonah Jameson |
| Joe Manganiello | ... | Flash Thompson |
| Gerry Becker | ... | Maximilian Fargas |
| Bill Nunn | ... | Joseph 'Robbie' Robertson |
| Jack Betts | ... | Henry Balkan |
| Stanley Anderson | ... | General Slocum |
| Ron Perkins | ... | Dr. Mendell Stromm |
| Michael Papajohn | ... | Carjacker |
| K.K. Dodds | ... | Simkins |
| Ted Raimi | ... | Hoffman |
| Bruce Campbell | ... | Ring Announcer |
| Elizabeth Banks | ... | Betty Brant |
| John Paxton | ... | Houseman |
| Tim De Zarn | ... | Philip Watson (as Tim deZarn) |
| Taylor Gilbert | ... | Madeline Watson |
| Randy Savage | ... | Bone Saw McGraw |
| Larry Joshua | ... | Wrestling Promoter |
| Timothy Patrick Quill | ... | Wrestling Arena Guard |
| Lisa Danielle | ... | Bone-ette |
| Natalie T. Yeo | ... | Bone-ette |
| Erica D. Porter | ... | Bone-ette |
| Kristen Davidson | ... | Bone-ette |
| Jason Padgett | ... | Flash's Crony |
| Shan Omar Huey | ... | Teacher |
| Sally Livingstone | ... | Girl on Bus |
| Evan Arnold | ... | Doctor |
| Jill Sayre | ... | Nurse |
| James Kevin Ward | ... | Project Coordinator (as James K. Ward) |
| David Holcomb | ... | Test Pilot |
| Octavia Spencer | ... | Check-In Girl |
| Brad Grunberg | ... | Heckler |
| Shane Habberstad | ... | Little Billy |
| Deborah Wakeham | ... | Billy's Mom |
| Rachael Bruce | ... | Times Square Child |
| Mackenzie Bryce | ... | Times Square Child |
| Julia Barry | ... | Times Square Child |
| Macy Gray | ... | Herself |
| Myk Watford | ... | Cop at Fire |
| Bill Calvert | ... | Fireman (as William Calvert) |
| Sylva Kelegian | ... | Mother at Fire |
| Kristen Marie Holly | ... | Young Lady at Fire |
| Ajay Mehta | ... | Cabbie |
| Peter Appel | ... | Cabbie |
| Scott Spiegel | ... | Marine Cop |
| Matt Smith | ... | Cop at Carjacking |
| Sara Ramirez | ... | Cop at Carjacking |
| Lucy Lawless | ... | Punk Rock Girl |
| Jayce Bartok | ... | Subway Guitarist |
| Maribel González | ... | Lady Dogwalker (as Maribel Gonzalez) |
| Amy Bouril | ... | Office Lady |
| Joe D'Onofrio | ... | Opinionated Cop (as Joseph D'Onofrio) |
| Jim Norton | ... | Surly Truck Driver |
| Corey Mendell Parker | ... | Chaperone in Tram |
| Ashley Edner | ... | Girl in Tram (as Ashley Louise Edner) |
| William Joseph Firth | ... | Boy in Tram |
| Alex Black | ... | Boy in Tram |
| Laura Gray | ... | Tram Group Mother |
| Joe Virzi | ... | New Yorker on Bridge |
| Michael Edward Thomas | ... | New Yorker on Bridge |
| Jeanie Fox | ... | New Yorker on Bridge |
| Robert Kerman | ... | Tugboat Captain |
|
| Ari Averbach | ... | Dancer (uncredited) |
| Joni Avery | ... | Cop (uncredited) |
| Rick Avery | ... | Cop (uncredited) |
| Margaret Baker | ... | Punk #2 (uncredited) |
| Amy Beth Bennett | ... | Jewelry Thief #2 (uncredited) |
| Brian Bennett | ... | Doorman (uncredited) |
| Camille Bennett | ... | High School Student (uncredited) |
| Andy Bray | ... | Boy carrying tray in Cafeteria (uncredited) |
| Jophery C. Brown | ... | Chef (uncredited) |
| Jacob Chambers | ... | Cop (uncredited) |
| Jillian Clare | ... | Crying Girl in Tram (uncredited) |
| Chris Coppola | ... | Kyle (uncredited) |
| Cody Cundiff | ... | World Unity Day attendee (uncredited) |
| Una Damon | ... | Lab Tour Guide (uncredited) |
| Chandra De Alessandro | ... | Cop (uncredited) |
| Mark De Alessandro | ... | Cop (uncredited) |
| Michael Patrick Dobkins | ... | Wrestiling Fan (uncredited) |
| Patrick Coleman Duncan | ... | Oscorp Lab Technician (uncredited) |
| Marcus Edward | ... | Screaming Fan at Wrestling Match (uncredited) |
| R.C. Everbeck | ... | Eddie Brock (scenes deleted) (uncredited) |
| Peter Genovese | ... | Fleeing World Unity Day Patron (uncredited) |
| Marcus Gorman | ... | Man in Street (uncredited) |
| Al Goto | ... | Cop (uncredited) |
| Juan M. Guerra | ... | City guy (uncredited) |
| Randy Hall | ... | Cop (uncredited) |
| Jesse Heiman | ... | Spectator at the scholl's fight. (uncredited) |
| Tia Dionne Hodge | ... | Uptown Woman (uncredited) |
| Kevin Jackson | ... | Bellman (uncredited) |
| Loren Janes | ... | Board of Directors Member (uncredited) |
| Andray Johnson | ... | Balkan's Aide (uncredited) |
| Claudia Katz | ... | Robbie's Assistant (uncredited) |
| Erik Kleven | ... | Chef (uncredited) |
| Stan Lee | ... | Man in Fair (uncredited) |
| Pete Macnamara | ... | Pentagon Officer (uncredited) |
| Joy Michelle Moore | ... | World's Fair mom (uncredited) |
| Justin Neill | ... | Flash's Crony (uncredited) |
| Philip Ng | ... | Diamond District Attendee (uncredited) |
| Debra Orenstein | ... | Doctor (uncredited) |
| Gary Otto | ... | New Yorker (uncredited) |
| Leroy Patterson | ... | World Unity Festival Attendant (uncredited) |
| Lance Polland | ... | Bonesaw Fan (uncredited) |
| January Pugh | ... | Mary Jane's Friend (uncredited) |
| Sumner Redstone | ... | Oscorp Board Member (uncredited) |
| Scott L. Schwartz | ... | Screaming Wrestler (uncredited) |
| Robair Sims | ... | Bellman (uncredited) |
| Richard Stephens | ... | Man on Brooklyn Bridge (uncredited) |
| Tammi Sutton | ... | Street Vendor (uncredited) |
| Lindsay Thompson | ... | Mary Jane's Friend (uncredited) |
| Lou Torres | ... | Enrique (uncredited) |
| Brigid Turner | ... | Featured Hot Girl (uncredited) |
| Benny Urquidez | ... | Mugger (uncredited) |
| Sean Valla | ... | Boat Light Man (uncredited) |
| Derek C. Wallace | ... | Homeless Man (uncredited) |
| John Wojnowski III | ... | Man in Street (uncredited) |
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